INCB3284

Published date: 2022-11-29 15:44:27
INCB3284 Structure
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Name INCB 3284 dimesylate CAS# 887401-93-6
Price ￥Inquiry/1g Purity 98.9%
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Period		 1 Day Stock In Stock
 Detail Product Information
INCB3284 is a potent, selective, and orally bioavailable hCCR2 Antagonist. INCB3284 exhibited an IC50 of 3.7 nM in antagonism of monocyte chemoattractant protein-1 binding to hCCR2, an IC50 of 4.7 nM in antagonism of chemotaxis activity, an IC50 of 84 μM in inhibition of the hERG potassium current, a free fraction of 58% in protein binding, high selectivity over other chemokine receptors and G-protein-coupled receptors, and acceptable oral bioavailability in rodents and primates. In human clinical trials, INCB3284 exhibited a pharmacokinetic profile suitable for once-a-day dosing (T 1/2 = 15 h).
Supplier/Manufacture

ShangHai DC Chemicals Co.,Ltd verified supplier

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2024-07-15 INCB 3284 dimesylate?
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2021-02-06 INCB 3284 dimesylate
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