M4K2234

Published date: 2022-06-22 21:57:40
M4K2234 Structure
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Name M4K2234 CAS# 2421141-51-5
Price $Inquiry/100mg $Inquiry/250mg $Inquiry/1g Purity 98.0%
Stocking
Period		 3 Day Stock 3
Product Webpage: https://www.dcchemicals.com/product_show-m4k2234.html
 Detail Product Information
M4K2234 is a potent, selective ALK1 (ACVRL1) and ALK2 (ACVR1) protein kinase inhibitor with IC50 of 7 and 14 nM, respectively.M4K2234 inhibits only ALK1/2 and one additional off target (TNIK) by kinome-wide screening against 375 protein kinases at 1 uM.M4K2234 demonstrated in cell based target engagement assays with an IC50 of 83nM for ALK1 and 13 nM for ALK2.M4K2234 exhibits only very weak potency against ALK4/5.M4K2234 affects phosphorylation of SMAD1/5/8 that corresponds to BMP branch of signalling which is mediated, besides others, also by ALK1/2 kinases.M4K2234 has only a very weak effect on SMAD2/3 phosphorylation that corresponds to TGF beta branch of signalling which is mediated mostly via ALK4/5/7.
Supplier/Manufacture

DC Chemicals Limited verified supplier

Chemsrc Level: Verified
Product #: 34963
Tel: 58447131
Address: Jinyu Rd100, pudong
Area: China
Contact: Tony Cao
Contact Phone #: 13564518121
Email: sales@dcchemicals.com
Website: http://www.dcchemicals.com
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M4K2234 price is $Inquiry/100mg. Find complete details about M4K2234 product information includes price/quote, purity, stocking period etc. from DC Chemicals Limited>>Mobile(AMP) version: M4K2234 Price from Supplier Brand DC Chemicals Limited

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