SKLB-03176

Published date: 2022-06-22 21:57:40
SKLB-03176 Structure
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Name SKLB-03176 CAS# 2609675-22-9
Price $500.0/5mg Purity 98.0%
Stocking
Period		 3 Day Stock 3
Product Webpage: https://www.dcchemicals.com/product_show-sklb-03176.html
 Detail Product Information
SKLB-03176 (SKLB03176) is a potent, selective, covalent EZH2 inhibitor with IC50 of 47 nM, covalently binds to the SAM pocket of EZH2.SKLB-03176 showed good inhibitory activity against mutations EZH2 Y641F, EZH2 Y641N, and EZH2A677G at 200 nM concentration.SKLB-03176 exhibited weak activity against other targets, such as 5 histone methyltransferases and more than 30 kinases, >50-fold selective for EZH2 over the highly homologous H3K27 methyltransferase EZH1 (IC50=2.45 uM).SKLB-03176 inhibited the activity of a variety of EZH2 mutants and significantly inhibited the expression of H3K27Me3 in cells.SKLB-03176 showed no cytotoxicity to normal cells.
Supplier/Manufacture

DC Chemicals Limited verified supplier

Chemsrc Level: Verified
Product #: 34963
Tel: 58447131
Address: Jinyu Rd100, pudong
Area: China
Contact: Tony Cao
Contact Phone #: 13564518121
Email: sales@dcchemicals.com
Website: http://www.dcchemicals.com
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SKLB-03176 price is $500.0/5mg. Find complete details about SKLB-03176 product information includes price/quote, purity, stocking period etc. from DC Chemicals Limited>>Mobile(AMP) version: SKLB-03176 Price from Supplier Brand DC Chemicals Limited

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