BLU-945
Published date: 2022-06-22 21:57:40
|
Name | BLU-945 | CAS# | 2660250-10-0 |
|---|---|---|---|---|
| Price | $600.0/100mg $1100.0/250mg $2200.0/1g | Purity | 98.0% | |
| Stocking Period |
3 Day | Stock | 3 | |
| Product Webpage: | https://www.dcchemicals.com/product_show-blu-945.html | |||
| Detail
Product Information
BLU-945 is a potent, mutant-selective inhibitor of EGFR T790M/C797S and EGFR+/T790M mutations (IC50 1000-fold selectivity over EGFR WT.BLU-945 achieves potent EGFR pathway inhibition in NCI-H1975 EGFRL858R/T790M, Ba/F3 EGFRL858R/T790M/C797S, and Ba/F3 EGFRex19del/T790M/C797S cell lines and a large window relative to EGFRWT inhibition.Oral administration of BLU-945 to tumor-bearing mice demonstrated potent EGFR pathway inhibition and anti-tumor activity at well-tolerated doses in the subcutaneous NCI-H1975 CDX model, and osimertinib-resistant CDX and PDX models. |
DC Chemicals Limited
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