(Rac)-CFT7455
Published date: 2022-06-22 21:57:40
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Name | CFT7455 | CAS# | 2504233-68-3 |
|---|---|---|---|---|
| Price | $Inquiry/100mg $Inquiry/250mg $Inquiry/1g | Purity | 98.0% | |
| Stocking Period |
3 Day | Stock | 3 | |
| Product Webpage: | https://www.dcchemicals.com/product_show-cft7455.html | |||
| Detail
Product Information
CFT7455 is a highly potent and selective degarder of IKZF1/3 with cereblon binding IC50 of 0.4 nM and picomolar DC50.Treatment of the KiJK cell line of anaplastic large cell lymphoma (ALCL) with CFT7455 for 6 hours led to an 89% reduction in IKZF1 protein levels.CFT7455 demonstrated potent antiproliferative activity across a panel of NHL cell lines with MYC, BCL2, and/or BCL6 translocations or rearrangements.CFT7455 is an orally bioavailable.CFT7455 achieved improved in vivo potency and efficacy, including deeper and more durable tumor regressions in models of ALCL, diffuse large B-cell lymphoma (DLBCL) and MCL in xenograft models. |
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