Thailanstatin A
Published date: 2021-12-17 15:49:26
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Name | Thailanstatin A | CAS# | 1426953-21-0 |
|---|---|---|---|---|
| Price | ￥1200.0/10mg | Purity | 98.0% | |
| Stocking Period |
1 Day | Stock | 3 | |
| Product Webpage: | https://www.dcchemicals.com/product_show-thailanstatin-a.html | |||
| Detail
Product Information
Thailanstatin A is an ultra-potent inhibitor of eukaryotic RNA splicing (IC50=650 nM). Thailanstatin A exerts effects via non-covalent binding to the SF3b subunit of the U2 snRNA subcomplex of the spliceosome and shows low-nM to sub-nM IC50s against multiple cancer cell lines. Thailanstatin A, a payload for ADCs, is conjugated to the lysines on trastuzumab yielding “linker-less” ADC. |
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