L748337
Published date: 2021-12-17 15:49:26
|
Name | L-748,337 | CAS# | 244192-94-7 |
|---|---|---|---|---|
| Price | ￥Inquiry/1g | Purity | 98.9% | |
| Stocking Period |
1 Day | Stock | In Stock | |
| Product Webpage: | https://www.dcchemicals.com/product_show-l748337.html | |||
| Detail
Product Information
L748337 is a potent β3-adrenergic receptor antagonist and displays selectivity over β1 and β2 receptors. The Ki values of L748337 for β3-, β2- and β1-adrenoceptors are 4.0 nM, 204 nM and 390 nM, respectively. L748337 couples predominantly to Gi to activate MAPK signaling and increases phosphorylation of Erk1/2 with pEC50 value of 11.6. L748337 can be used for the research of cancer, nonalcoholic fatty liver disease (NAFLD), and cardiovascular related diseases. |
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