Name | denatonium benzoate | CAS# | 3734-33-6 | |
---|---|---|---|---|
Price | $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg | Purity | 98.0% | |
Stocking Period |
3 Day | Stock | 3 | |
Product Webpage: | https://www.dcchemicals.com/product_show-Denatonium.html |
Detail
Product Information
Denatonium, also known as Bitrex, is a bitterant (or bitter agonist). Denatonium activates bitter taste receptors on many cell types and plays important roles in chemical release, ciliary beating and smooth muscle relaxation through intracellular Ca(2+)-dependent pathways. Denatonium significantly effects cellular morphology, decreases cell proliferation and reduces the number of cells in S phase in a dose-dependent manner. Denatonium causes large amplitude swelling of mitochondria, which was confirmed by the loss of mitochondrial membrane potential, the down-regulation of Bcl-2 protein and the subsequent enhancement of the mitochondrial release of cytochrome c and Smac/DIABLO after denatonium treatment. |