Name | TED-347 | CAS# | 2378626-29-8 | |
---|---|---|---|---|
Price | $700.0/100mg $1200.0/250mg $2400.0/1g | Purity | 98.0% | |
Stocking Period |
3 Day | Stock | 3 | |
Product Webpage: | http://www.dcchemicals.com/product_show-TED-347.html |
Detail
Product Information
TED-347 is a potent, irreversible, covalent and allosteric inhibitor at YAP-TEAD protein-protein interaction with an EC50 of 5.9 μM for TEAD4⋅Yap1 protein-protein interaction. TED-347 specifically and covalently bonds with Cys-367 within the central pocket of TEAD4 with a Ki of 10.3 μM. TED-347 blocks TEAD transcriptional activity and has antitumor activity[1]. |