Hydroxy desmethyl Bosentan
Published date: 2020-12-18 22:54:27
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Name | Hydroxy Desmethyl Bosentan | CAS# | 253688-62-9 |
|---|---|---|---|---|
| Price | $Inquiry/1g | Purity | 98.0% | |
| Stocking Period |
3 Day | Stock | 3 | |
| Product Webpage: | https://www.dcchemicals.com/product_show-Hydroxy-desmethyl-Bosentan.html | |||
| Detail
Product Information
Hydroxy desmethyl Bosentan (Ro 64-105) is a Bosentan metabolism produced by the cytochrome P450 enzymes CYP2C9 and CYP3A4 in the liver. Bosentan is a competitive and dual antagonist of endothelin-1 (ET) for the ETA and ETB receptors with Ki of 4.7 nM and 95 nM in human SMC, respectively. Bosentan can be used in treatment of pulmonary arterial hypertension. |
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