D-α-Hydroxyglutaric acid
Published date: 2020-12-18 22:54:27
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Name | D-α-Hydroxyglutaric acid | CAS# | 13095-47-1 |
|---|---|---|---|---|
| Price | $Inquiry/250mg $Inquiry/100mg $Inquiry/1g | Purity | 98.0% | |
| Stocking Period |
3 Day | Stock | 3 | |
| Product Webpage: | https://www.dcchemicals.com/product_show-D-alpha-Hydroxyglutaric_acid.html | |||
| Detail
Product Information
D-α-Hydroxyglutaric acid ((R)-2-Hydroxypentanedioic acid) is the principal metabolite accumulating in neurometabolic disease D-2-hydroxyglutaric aciduria. D-α-Hydroxyglutaric acid is a weak competitive antagonist of α-ketoglutarate (α-KG) and inhibits multiple α-KG-dependent dioxygenases with a Ki of 10.87 mM. D-α-Hydroxyglutaric acid increases reactive oxygen species (ROS) production. D-α-Hydroxyglutaric acid binds and inhibits ATP synthase and inhibits mTOR signaling. |
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