Setmelanotide acetate

Published date: 2020-12-18 22:54:27

Setmelanotide acetate Structure
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Name RM-493 CAS# 1504602-49-6
Price $600.0/100mg $1100.0/250mg $1950.0/1g Purity 98.0%
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Product Webpage: http://www.dcchemicals.com/product_show-RM-493.html
 Detail Product Information
Setmelanotide is a peptide drug and investigational anti-obesity medication which acts as a selective agonist of the MC4 receptor. Setmelanotide binds to and activates MC4 receptors in the paraventricular nucleus (PVN) of the hypothalamus and in the lateral hypothalamic area (LHA), areas involved in the regulation of appetite, and this action is thought to underlie its appetite suppressant effects. Setmelanotide increases resting energy expenditure in both obese animals and humans. Setmelanotide has been reported to possess the following activity profile (cAMP, EC50): MC4 (0.27 nM) > MC3 (5.3 nM) ≈ MC1 (5.8 nM) > MC5 (1600 nM) ? MC2 (>1000 nM).

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