FF-10101

Published date: 2020-01-06 17:06:19

FF-10101 Structure
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Name FLT3-IN-1 CAS# 1472797-69-5
Price $Inquiry/100mg $Inquiry/250mg $Inquiry/1g Purity 98.0%
Stocking
Period
3 Day Stock 3
Product Webpage: http://www.dcchemicals.com/product_show-DC11000.html
 Detail Product Information
FF-10101 is a novel potent, selective, irreversible FLT3 inhibitor with IC50 of 0.20 and 0.16 nM for Wt FLT3 and FLT3 (D835Y); potently inhibits the phosphorylation of FLT3-ITD than that of FLT3-ITD-C695S (IC50=2.4 nM and 79 nM, respectively) binds to C695 while maintaining the binding ability to the active or inactive conformation of FLT3; shows potent growth inhibitory effects on human AML cell lines harboring FLT3-ITD, MOLM-13, MOLM-14, and MV4-11, and types of mutant FLT3-expressing 32D cells including quizartinib-resistant mutations at D835, Y842, and F691 residues in the FLT3 kinase domain; FF-10101 demonstrates antileukemic effects in vitro and in vivo, orally acitve.

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DC Chemicals Limited verified supplier

Chemsrc Level: Verified
Product #: 34961
Tel: 58447131
Address: Jinyu Rd100, pudong
Area: China
Contact: Tony Cao
Contact Phone #: 13564518121
Email: sales@dcchemicals.com
Website: http://www.dcchemicals.com
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