Name | FLT3-IN-1 | CAS# | 1472797-69-5 | |
---|---|---|---|---|
Price | $Inquiry/100mg $Inquiry/250mg $Inquiry/1g | Purity | 98.0% | |
Stocking Period |
3 Day | Stock | 3 | |
Product Webpage: | http://www.dcchemicals.com/product_show-DC11000.html |
Detail
Product Information
FF-10101 is a novel potent, selective, irreversible FLT3 inhibitor with IC50 of 0.20 and 0.16 nM for Wt FLT3 and FLT3 (D835Y); potently inhibits the phosphorylation of FLT3-ITD than that of FLT3-ITD-C695S (IC50=2.4 nM and 79 nM, respectively) binds to C695 while maintaining the binding ability to the active or inactive conformation of FLT3; shows potent growth inhibitory effects on human AML cell lines harboring FLT3-ITD, MOLM-13, MOLM-14, and MV4-11, and types of mutant FLT3-expressing 32D cells including quizartinib-resistant mutations at D835, Y842, and F691 residues in the FLT3 kinase domain; FF-10101 demonstrates antileukemic effects in vitro and in vivo, orally acitve. |