CGP60474
Modify Date: 2026-08-06 17:17:32
CGP60474 structure
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Common Name | CGP60474 | ||
|---|---|---|---|---|
| CAS Number | 164658-13-3 | Molecular Weight | 355.82100 | |
| Density | 1.356g/cm3 | Boiling Point | 630.6ºC at 760mmHg | |
| Molecular Formula | C18H18ClN5O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 335.2ºC | |
Use of CGP60474CGP60474 is a potent VEGFR-2 inhibitor, with an IC50 of 84 nM, and also an ATP-competitive PKC inhibitor. |
| Name | 3-[[4-[2-(3-chloroanilino)pyrimidin-4-yl]pyridin-2-yl]amino]propan-1-ol |
|---|---|
| Synonym | More Synonyms |
| Description | CGP60474 is a potent VEGFR-2 inhibitor, with an IC50 of 84 nM, and also an ATP-competitive PKC inhibitor. |
|---|---|
| Related Catalog | |
| Target |
VEGFR-2:84 nM (IC50) PKC |
| In Vitro | CGP60474 (Compound A) is a potent VEGFR-2 inhibitor, with an IC50 of 84 nM[1]. CGP60474 is also a PKC inhibitor, with competitive kinetics relative to ATP[2]. |
| References |
| Density | 1.356g/cm3 |
|---|---|
| Boiling Point | 630.6ºC at 760mmHg |
| Molecular Formula | C18H18ClN5O |
| Molecular Weight | 355.82100 |
| Flash Point | 335.2ºC |
| Exact Mass | 355.12000 |
| PSA | 86.19000 |
| LogP | 3.22480 |
| Vapour Pressure | 9.02E-17mmHg at 25°C |
| Index of Refraction | 1.685 |
| InChIKey | IYNDTACKOAXKBJ-UHFFFAOYSA-N |
| SMILES | OCCCNc1cc(-c2ccnc(Nc3cccc(Cl)c3)n2)ccn1 |
| Storage condition | 2-8℃ |
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Name: SANGER: Inhibition of human NCI-H1522 cell growth in a cell viability assay.
Source: ChEMBL
Target: NCI-H1522
External Id: CHEMBL2363474
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|
Name: Primary qHTS assay for inhibitors of alpha-synuclein gene (SNCA) expression
Source: NCGC
External Id: SNCA-p-activity-luciferase
|
|
Name: SANGER: Inhibition of human NCI-H1436 cell growth in a cell viability assay.
Source: ChEMBL
Target: NCI-H1436
External Id: CHEMBL2363472
|
|
Name: Fluorescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_AG_FLUO8_1536_1X%ACT PRUN
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|
Name: SANGER: Inhibition of human NCI-H128 cell growth in a cell viability assay.
Source: ChEMBL
Target: NCI-H128
External Id: CHEMBL2363466
|
|
Name: SANGER: Inhibition of human NCI-H1155 cell growth in a cell viability assay.
Source: ChEMBL
Target: NCI-H1155
External Id: CHEMBL2363465
|
|
Name: SANGER: Inhibition of human NCI-H1092 cell growth in a cell viability assay.
Source: ChEMBL
Target: NCI-H1092
External Id: CHEMBL2363464
|
|
Name: SANGER: Inhibition of human NCI-H1417 cell growth in a cell viability assay.
Source: ChEMBL
Target: NCI-H1417
External Id: CHEMBL2363471
|
|
Name: SANGER: Inhibition of human NCI-H1395 cell growth in a cell viability assay.
Source: ChEMBL
Target: NCI-H1395
External Id: CHEMBL2363470
|
|
Name: SANGER: Inhibition of human NCI-H1355 cell growth in a cell viability assay.
Source: ChEMBL
Target: NCI-H1355
External Id: CHEMBL2363469
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| GNF-Pf-88 |
| 1-Propanol,3-((4-(2-((3-chlorophenyl)amino)-4-pyrimidinyl)-2-pyridinyl)amino) |
| UNII-16IP6G5MLC |
| CGP60474 |