Entecavir
Published date: 2018-07-18 16:44:31
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Name | Entecavir | CAS# | 142217-69-4 |
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| Price | $Inquiry/1kg | Purity | 99.9% | |
| Stocking Period |
Inquiry | Stock | In Stock |
| Detail
Product Information
Names [ Name ]: entecavir (anhydrous) [ Synonym ]: More Synonyms Chemical & Physical Properties [ Density ]: 1.8±0.1 g/cm3 [ Boiling Point ]: 734.2ºC at 760 mmHg [ Melting Point ]: 249-252ºC [ Molecular Formula ]: C12H15N5O3 [ Molecular Weight ]: 277.279 [ Flash Point ]: 397.9ºC [ Exact Mass ]: 277.117493 [ PSA ]: 130.05000 [ LogP ]: -0.96 [ Index of Refraction ]: 1.837 MSDS Material Safety Data Sheet Section1. Identification of the substance Product Name: Entecavir Synonyms: Section2. Hazards identification
Harmful by inhalation, in contact with skin, and if swallowed. Section3. Composition/information on ingredients. Ingredient name:Entecavir CAS number:142217-69-4 Section4. First aid measures Skin contact:Immediately wash skin with copious amounts of water for at least 15 minutes while removing contaminated clothing and shoes. If irritation persists, seek medical attention. Eye contact:Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical attention. Inhalation:Remove to fresh air. In severe cases or if symptoms persist, seek medical attention. Ingestion:Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention. Section5. Fire fighting measures In the event of a fire involving this material, alone or in combination with other materials, use dry powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus should be worn. Section6. Accidental release measures Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national standards. Respiratory precaution:Wear approved mask/respirator Hand precaution:Wear suitable gloves/gauntlets Skin protection:Wear suitable protective clothing Eye protection:Wear suitable eye protection Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container for disposal. See section 12. Environmental precautions: Do not allow material to enter drains or water courses. Section7. Handling and storage Handling:This product should be handled only by, or under the close supervision of, those properly qualified in the handling and use of potentially hazardous chemicals, who should take into account the fire, health and chemical hazard data given on this sheet. Storage:Store in closed vessels, refrigerated. Section8. Exposure Controls / Personal protection Engineering Controls: Use only in a chemical fume hood. Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles. General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse. Section9. Physical and chemical properties Appearance:Not specified Boiling point:No data Melting point:No data Flash point:No data Density:No data Molecular formula: C12H15N5O3 Molecular weight: 277.3 Section10. Stability and reactivity Conditions to avoid: Heat, flames and sparks. Materials to avoid: Oxidizing agents. Possible hazardous combustion products: Carbon monoxide, nitrogen oxides. Section11. Toxicological information No data. Section12. Ecological information No data. Section13. Disposal consideration Arrange disposal as special waste, by licensed disposal company, in consultation with local waste disposal authority, in accordance with national and regional regulations. Section14. Transportation information Non-harzardous for air and ground transportation. Section15. Regulatory information No chemicals in this material are subject to the reporting requirements of SARA Title III, Section 302, or have known CAS numbers that exceed the threshold reporting levels established by SARA Title III, Section 313. SECTION 16 - ADDITIONAL INFORMATION N/A Safety Information [ RIDADR ]: NONH for all modes of transport [ HS Code ]: 2933990090 Synthetic RoutePrevious 1/19 Next 6-chloroentecavir 701278-58-2 6-chloroentecav... ~71% Entecavir 142217-69-4 Entecavir Literature: HANMI HOLDINGS CO., LTD. Patent: US2011/251387 A1, 2011 ; Location in patent: Page/Page column 8 ; tert-butyl (6-iodo-9-((4aR,6S,7aS)-2-methyl-5-methylenehexahydrocyclopenta[d][1,3]dioxin-6-yl)-9H-purin-2-yl)carbamate 1328921-77-2 tert-butyl (6-i... ~88% Entecavir 142217-69-4 Entecavir Literature: ScinoPharm Taiwan, Ltd. Patent: US2011/201809 A1, 2011 ; Location in patent: Page/Page column 18 ; 6-(benzyloxy)-9-((4aR,6S,7aS)-5-methylene-2-phenylhexahydrocyclopenta[d][1,3]dioxin-6-yl)-N-(trimethylsilyl)-9H-purin-2-amine 1351691-93-4 6-(benzyloxy)-9... ~86% Entecavir 142217-69-4 Entecavir Literature: ALPHORA RESEARCH INC.; ALBERICO, Dino; CLAYTON, Joshua; DIXON, Craig; GORIN, Boris Patent: WO2011/150512 A1, 2011 ; Location in patent: Page/Page column 11 ; Precursor & DownStream Precursor 4 6-chloroentecavir Structure CAS#:701278-58-2 6-chloroentecavir 6-(benzyloxy)-9-((4aR,6S,7aS)-5-methylene-2-phenylhexahydrocyclopenta[d][1,3]dioxin-6-yl)-N-(trimethylsilyl)-9H-purin-2-amine Structure CAS#:1351691-93-4 6-(benzyloxy)-9... 9-[(1S,3R,4S)-4-tert-butyldimethylsilyloxy-3-(tert-butyldimethylsilyloxymethyl)-2-methylene-cyclopentyl]-6-chloro-9H-purine-2-carbamic acid tert-butyl ester Structure CAS#:1354715-15-3 9-[(1S,3R,4S)-4... 6-chloro-9-[(1S,3R,4S)-4-hydroxy-3-hydroxymethyl-2-methylene-cyclopentyl]-N-(tert-butyloxycarbonyl)-9H-purine-2-carbamic acid tert-butyl ester Structure CAS#:1354715-31-3 6-chloro-9-[(1S... DownStream 0 Customs [ HS Code ]: 2933990090 [ Summary ]: 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% Articles18More Articles Formation of covalently closed circular DNA in Hep38.7-Tet cells, a tetracycline inducible hepatitis B virus expression cell line. Biochem. Biophys. Res. Commun. 452(3) , 315-21, (2014) Hepatitis B virus (HBV) covalently closed circular DNA (cccDNA) plays a central role in chronic HBV infection. However, analysis of the molecular mechanism of cccDNA formation is difficult because of ... Detail Influence of the basal core promoter and precore mutation on replication of hepatitis B virus and antiviral susceptibility of different genotypes. J. Med. Virol. 87(4) , 601-8, (2015) Mutations in the basal core promoter (BCP) and precore (PC) regions of the hepatitis B virus (HBV) are more common in genotypes B and C than in genotype A, suggesting that these mutations might affect... Detail Decreased liver distribution of entecavir is related to down-regulation of Oat2/Oct1 and up-regulation of Mrp1/2/3/5 in rat liver fibrosis. Eur. J. Pharm. Sci. 71 , 73-9, (2015) We aimed to elucidate whether entecavir was taken-up into liver by transporters and clarify the possible molecular mechanisms of changes in the distribution of entecavir in rat liver fibrosis.Thioacet... Detail Synonyms 2-Amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl]-1,9-dihydro-6H-purin-6-one entecavir (anhydrous) 6H-Purin-6-one, 2-amino-1,9-dihydro-9-((1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl)- 2-amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylidenecyclopentyl]-3H-purin-6-one 2-amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylidenecyclopentyl]-1,9-dihydro-6H-purin-6-one 6H-Purin-6-one, 2-amino-1,9-dihydro-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl]- Baraclude entecavir 9H-purin-6-ol, 2-amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl]- UNII-NNU2O4609D 2-amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylidenecyclopentyl]-9H-purin-6-ol More
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