Kukoamine A
Kukoamine A structure
|
Common Name | Kukoamine A | ||
|---|---|---|---|---|
| CAS Number | 75288-96-9 | Molecular Weight | 530.656 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 872.1±65.0 °C at 760 mmHg | |
| Molecular Formula | C28H42N4O6 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 481.2±34.3 °C | |
Use of Kukoamine AKukoamine A is a natural occurring spermine derivative, acts as a potent inhibitor of trypanothione reductase (Ki, 1.8 μM), with antihypertensive activity[1]. |
Summary: N1,N12-bis(dihydrocaffeoyl)spermine (Kukoamine A), Chinese name: 地骨皮甲素, CAS number: 75288-96-9, molecular formula: C28H42N4O6, molecular weight: 530.656, for research-use only, not for medical or clinical usage.
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | N1,N12-bis(dihydrocaffeoyl)spermine |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Kukoamine A is a natural occurring spermine derivative, acts as a potent inhibitor of trypanothione reductase (Ki, 1.8 μM), with antihypertensive activity[1]. |
|---|---|
| Related Catalog | |
| Target |
Ki: 1.8 μM (Trypanothione reductase)[1] |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 872.1±65.0 °C at 760 mmHg |
| Molecular Formula | C28H42N4O6 |
| Molecular Weight | 530.656 |
| Flash Point | 481.2±34.3 °C |
| Exact Mass | 530.310425 |
| PSA | 163.18000 |
| LogP | -0.17 |
| Vapour Pressure | 0.0±0.3 mmHg at 25°C |
| Index of Refraction | 1.588 |
| InChIKey | IOLDDENZPBFBHV-UHFFFAOYSA-N |
| SMILES | O=C(CCc1ccc(O)c(O)c1)NCCCNCCCCNCCCNC(=O)CCc1ccc(O)c(O)c1 |
This table contains target information, in‑vitro & in‑vivo assay data for this compound.
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Name: Antioxidant activity against AAPH-induced lipid peroxidation assessed as inhibition o...
Source: ChEMBL
Target: N/A
External Id: CHEMBL1638703
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Name: Antioxidant activity of the compound assessed as reducing activity of DPPH at 0.1 mM ...
Source: ChEMBL
Target: NON-PROTEIN TARGET
External Id: CHEMBL1638818
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|
Name: Antioxidant activity of the compound assessed as reducing activity of DPPH at 0.1 mM ...
Source: ChEMBL
Target: NON-PROTEIN TARGET
External Id: CHEMBL1638819
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|
Name: Cytotoxicity against RAMEC assessed as cell viability after 24 hrs by MTT assay
Source: ChEMBL
Target: N/A
External Id: CHEMBL1638820
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Name: Natural log of the value in (uM) of inhibition constant was tested against Trypanothi...
Source: ChEMBL
Target: Trypanothione reductase
External Id: CHEMBL817698
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Name: Antiinflammatory activity in Fisher rat assessed as inhibition of carrageenan-induced...
Source: ChEMBL
Target: Rattus norvegicus
External Id: CHEMBL1638821
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This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| .N1,N14-bis(dihydrocaffeoyl)spermine |
| Kukoamine A |
| N,N'-[butane-1,4-diylbis(iminopropane-3,1-diyl)]bis[3-(3,4-dihydroxyphenyl)propanamide] |
| bis-dihydrocaffeoylspermine |
| N,N'-[1,4-Butanediylbis(imino-3,1-propanediyl)]bis[3-(3,4-dihydroxyphenyl)propanamide] |
| .kukoamine A |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the SMILES notation of N1,N12-bis(dihydrocaffeoyl)spermine? |
| A: SMILES notation of N1,N12-bis(dihydrocaffeoyl)spermine is O=C(CCc1ccc(O)c(O)c1)NCCCNCCCCNCCCNC(=O)CCc1ccc(O)c(O)c1. |
| Q: What English synonyms does N1,N12-bis(dihydrocaffeoyl)spermine have? |
| A: English synonyms of N1,N12-bis(dihydrocaffeoyl)spermine: .N1,N14-bis(dihydrocaffeoyl)spermine, Kukoamine A, N,N'-[butane-1,4-diylbis(iminopropane-3,1-diyl)]bis[3-(3,4-dihydroxyphenyl)propanamide], bis-dihydrocaffeoylspermine, N,N'-[1,4-Butanediylbis(imino-3,1-propanediyl)]bis[3-(3,4-dihydroxyphenyl)propanamide], .kukoamine A. |
| Q: What is the polar surface area (PSA) of N1,N12-bis(dihydrocaffeoyl)spermine? |
| A: Polar surface area (PSA) of N1,N12-bis(dihydrocaffeoyl)spermine is 163.18000. |
| Q: What is the boiling point of N1,N12-bis(dihydrocaffeoyl)spermine? |
| A: Boiling point of N1,N12-bis(dihydrocaffeoyl)spermine is 872.1±65.0 °C at 760 mmHg. |
| Q: What are the uses of N1,N12-bis(dihydrocaffeoyl)spermine? |
| A: Main uses of N1,N12-bis(dihydrocaffeoyl)spermine: Kukoamine A is a natural occurring spermine derivative, acts as a potent inhibitor of trypanothione reductase (Ki, 1.8 μM), with antihypertensive activity[1]. |
| Q: What is the InChIKey of N1,N12-bis(dihydrocaffeoyl)spermine? |
| A: InChIKey of N1,N12-bis(dihydrocaffeoyl)spermine is IOLDDENZPBFBHV-UHFFFAOYSA-N. |
| Q: What is the English name of N1,N12-bis(dihydrocaffeoyl)spermine? |
| A: The English name of N1,N12-bis(dihydrocaffeoyl)spermine is N1,N12-bis(dihydrocaffeoyl)spermine. |
| Q: What is the molecular weight of N1,N12-bis(dihydrocaffeoyl)spermine? |
| A: Molecular weight of N1,N12-bis(dihydrocaffeoyl)spermine is 530.656. |
| Q: What is the molecular formula of N1,N12-bis(dihydrocaffeoyl)spermine? |
| A: Molecular formula of N1,N12-bis(dihydrocaffeoyl)spermine is C28H42N4O6. |
| Q: What is the LogP of N1,N12-bis(dihydrocaffeoyl)spermine? |
| A: LogP of N1,N12-bis(dihydrocaffeoyl)spermine is -0.17. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| BioBioPha |
| naturewill |