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Kukoamine A

Names

[ CAS No. ]:
75288-96-9

[ Name ]:
Kukoamine A

[Synonym ]:
.N1,N14-bis(dihydrocaffeoyl)spermine
Kukoamine A
N,N'-[butane-1,4-diylbis(iminopropane-3,1-diyl)]bis[3-(3,4-dihydroxyphenyl)propanamide]
bis-dihydrocaffeoylspermine
N,N'-[1,4-Butanediylbis(imino-3,1-propanediyl)]bis[3-(3,4-dihydroxyphenyl)propanamide]
Benzenepropanamide, N,N'-[1,4-butanediylbis(imino-3,1-propanediyl)]bis[3,4-dihydroxy-
.kukoamine A

Biological Activity

[Description]:

Kukoamine A is a natural occurring spermine derivative, acts as a potent inhibitor of trypanothione reductase (Ki, 1.8 μM), with antihypertensive activity[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease
Signaling Pathways >> Others >> Others

[Target]

Ki: 1.8 μM (Trypanothione reductase)[1]


[References]

[1]. Ponasik JA, et al. Kukoamine A and other hydrophobic acylpolyamines: potent and selective inhibitors of Crithidia fasciculata trypanothione reductase. Biochem J. 1995 Oct 15;311 ( Pt 2):371-5.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
872.1±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C28H42N4O6

[ Molecular Weight ]:
530.656

[ Flash Point ]:
481.2±34.3 °C

[ Exact Mass ]:
530.310425

[ PSA ]:
163.18000

[ LogP ]:
-0.17

[ Vapour Pressure ]:
0.0±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.588

Related Compounds

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