Agoniadin

Modify Date: 2025-08-22 16:43:37

Agoniadin structure	Common Name	Agoniadin
	CAS Number	511-89-7	Molecular Weight	470.42
	Density	1.6±0.1 g/cm3	Boiling Point	771.4±60.0 °C at 760 mmHg
	Molecular Formula	C₂₁H₂₆O₁₂	Melting Point	156-158°; mp 224-225°
	MSDS	Chinese USA	Flash Point	269.2±26.4 °C

Use of Agoniadin

Plumieride is an antifungal agent. Plumieride has strong fungitoxicity against some dermatophytes. Plumieride has little cytotoxic activity against the P388 leukaemia cell line with an IC50 of 85 μg/mL[1].

Name	methyl (1S,4aS,7R,7aS)-4'-[(1S)-1-hydroxyethyl]-5'-oxo-1-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyspiro[4a,7a-dihydro-1H-cyclopenta[c]pyran-7,2'-furan]-4-carboxylate
Synonym	More Synonyms

Description	Plumieride is an antifungal agent. Plumieride has strong fungitoxicity against some dermatophytes. Plumieride has little cytotoxic activity against the P388 leukaemia cell line with an IC50 of 85 μg/mL[1].
Related Catalog	Research Areas >> Cancer Research Areas >> Infection Signaling Pathways >> Anti-infection >> Fungal
References	[1]. Tiwari TN, et al. Plumieride from Allamanda cathartica as an antidermatophytic agent. Phytother Res. 2002 Jun;16(4):393-4.

Density	1.6±0.1 g/cm3
Boiling Point	771.4±60.0 °C at 760 mmHg
Melting Point	156-158°; mp 224-225°
Molecular Formula	C₂₁H₂₆O₁₂
Molecular Weight	470.42
Flash Point	269.2±26.4 °C
Exact Mass	470.142426
PSA	181.44000
LogP	-4.23
Vapour Pressure	0.0±6.0 mmHg at 25°C
Index of Refraction	1.645
InChIKey	AOPMSFXOYJXDNJ-IRFSQMTFSA-N
SMILES	COC(=O)C1=COC(OC2OC(CO)C(O)C(O)C2O)C2C1C=CC21C=C(C(C)O)C(=O)O1

Agoniadin MSDS(Chinese)

Hazard Codes	Xi
RIDADR	NONH for all modes of transport

Precursor 0
DownStream 1
CAS#:132586-69-7 15-DeMethylpluM...

Assessment of the genotoxic and mutagenic properties of Himatanthus articulatus bark extracts used as phytotherapeutic drug in the Amazon.

J. Ethnopharmacol. 147(2) , 474-80, (2013)

Himatanthus articulatus (Apocynaceae) is a plant native to the Amazon, popularly used to treat external ulcers, tumors, inflammations, cancer, syphilis and malaria.To investigate the in vivo genotoxic...

Bioactive iridoids and a new lignan from Allamanda cathartica and Himatanthus fallax from the Suriname rainforest.

J. Nat. Prod. 60(12) , 1294-7, (1997)

Bioassay-guided fractionation of the EtOAc extract of both Allamanda cathartica and Himatanthus fallax (Apocynaceae) using the Sc-7 yeast strain resulted in the isolation of the weakly cytotoxic isopl...

Structural modifications of plumieride isolated from Plumeria bicolor and the effect of these modifications on in vitro anticancer activity.

J. Org. Chem. 69(19) , 6165-72, (2004)

Plumieride was isolated as one of the major components from the biologically active methanolic extract of the bark of Plumeria bicolor (family Apocynaceae). For investigating the effect of substituent...

Name: Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (...
Source: NCGC
External Id: IP6K1-p1

Name: Inhibition of HIV1 RT
Source: ChEMBL
Target: Reverse transcriptase/RNaseH
External Id: CHEMBL1018093

Name: Cytotoxicity against human breast cancer cells
Source: ChEMBL
Target: NON-PROTEIN TARGET
External Id: CHEMBL1017530

Name: HIV Enzyme Data
Source: NIAID
Target: N/A
External Id: HIV Enzyme Data

Name: Cytotoxicity against human melanoma cells
Source: ChEMBL
Target: NON-PROTEIN TARGET
External Id: CHEMBL1016691

Name: Small-molecule inhibitors of ST2 (IL1RL1)
Source: 20881
Target: interleukin-1 receptor-like 1 isoform [homo sapiens]
External Id: ST2_IL33_Inhibitors_Primary_Screening_77700

Name: Cytotoxicity against human colon cancer cells
Source: ChEMBL
Target: NON-PROTEIN TARGET
External Id: CHEMBL1017532

Name: Cytotoxicity against human lung cancer cells
Source: ChEMBL
Target: NON-PROTEIN TARGET
External Id: CHEMBL1017531

Name: Cytotoxicity against human HT1080 cells
Source: ChEMBL
Target: HT-1080
External Id: CHEMBL1016690

Name: Cytotoxicity against mouse P388 cells
Source: ChEMBL
Target: P388
External Id: CHEMBL1017534

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1-(b-D-Glucopyranosyloxy)-4a,7a-dihydro-4'-(1-hydroxyethyl)-5'-oxospiro[cyclopenta[c]pyran-7(1H),2'(5'H)-furan]-4-carboxylic Acid Methyl Ester

Agoniadin

Methyl (1S,4aS,7R,7aS)-1-(β-D-glucopyranosyloxy)-4'-[(1S)-1-hydroxyethyl]-5'-oxo-4a,7a-dihydro-1H,5'H-spiro[cyclopenta[c]pyran-7,2'-furan]-4-carboxylate

Plumieride