EPZ015866(GSK591)

Modify Date: 2026-07-03 19:39:36

EPZ015866(GSK591) structure	Common Name	EPZ015866(GSK591)
	CAS Number	1616391-87-7	Molecular Weight	380.483
	Density	1.3±0.1 g/cm3	Boiling Point	648.4±55.0 °C at 760 mmHg
	Molecular Formula	C₂₂H₂₈N₄O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	345.9±31.5 °C

Use of EPZ015866(GSK591)

EPZ015866 is a potent and selective inhibitor of protein methyltransferase 5 (PRMT5) with an IC50 of 22 nM.

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name	2-(Cyclobutylamino)-N-[(2S)-3-(3,4-dihydro-2(1H)-isoquinolinyl)-2-hydroxypropyl]isonicotinamide
Synonym	More Synonyms

This table contains bioactivity, target information and biological‑assay experimental data of this compound.

Description	EPZ015866 is a potent and selective inhibitor of protein methyltransferase 5 (PRMT5) with an IC50 of 22 nM.
Related Catalog	Signaling Pathways >> Epigenetics >> Histone Methyltransferase Research Areas >> Cancer
Target	IC50: 22 nM (PRMT5)[1]
References	[1]. [1] Kenneth W. Duncan et al. Structure and Property Guided Design in the Identification of PRMT5 Tool Compound EPZ015666. ACS Med. Chem. Lett., 2016, 7 (2), pp 162-166. [2]. [2] Elayne Chan-Penebre et al. A selective inhibitor of PRMT5 with in vivo and in vitro potency in MCL models. Nature Chemical Biology 11, 2015, 432-437

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density	1.3±0.1 g/cm3
Boiling Point	648.4±55.0 °C at 760 mmHg
Molecular Formula	C₂₂H₂₈N₄O₂
Molecular Weight	380.483
Flash Point	345.9±31.5 °C
Exact Mass	380.221222
LogP	3.66
Vapour Pressure	0.0±2.0 mmHg at 25°C
Index of Refraction	1.645
InChIKey	TWKYXZSXXXKKJU-FQEVSTJZSA-N
SMILES	O=C(NCC(O)CN1CCc2ccccc2C1)c1ccnc(NC2CCC2)c1
Storage condition	-20℃

This table contains target information, in‑vitro & in‑vivo assay data for this compound.

Name: Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (...
Source: NCGC
External Id: IP6K1-p1

Name: Thermal Shift Assay. Domain: start/stop: M1-L298
Source: ChEMBL
Target: Cyclin-dependent kinase 2
External Id: CHEMBL5062802

Name: Cytotoxicity counterscreen for inhibitors of SARS-CoV-2 cell entry
Source: NCGC
Target: N/A
External Id: TRND-SARS-CoV-2-cytotox-48hr

Name: Primary qHTS to identify inhibitors of SARS-CoV-2 cell entry
Source: NCGC
External Id: TRND-SARS-CoV-2-PP

Name: Inhibition of PRMT5 in mouse oligodendrocyte progenitor cells assessed as decrease in...
Source: ChEMBL
Target: Protein arginine N-methyltransferase 5
External Id: CHEMBL5712508

Name: Inhibition of PRMT5 in mouse oligodendrocyte progenitor cells assessed as increase in...
Source: ChEMBL
Target: Protein arginine N-methyltransferase 5
External Id: CHEMBL5712507

Name: Effect on cell proliferation in mouse oligodendrocyte progenitor cells assessed as Ki...
Source: ChEMBL
Target: N/A
External Id: CHEMBL5712510

Name: Inhibition of PRMT5 in Trp53-/- mouse oligodendrocyte progenitor cells assessed as re...
Source: ChEMBL
Target: Protein arginine N-methyltransferase 5
External Id: CHEMBL5712509

Name: Inhibition of PRMT5 in Trp53fl/fl wild type mouse oligodendrocyte progenitor cells as...
Source: ChEMBL
Target: Protein arginine N-methyltransferase 5
External Id: CHEMBL5712512

Name: Effect on cell proliferation in Trp53fl/fl wild type mouse oligodendrocyte progenitor...
Source: ChEMBL
Target: N/A
External Id: CHEMBL5712511

Total 166, Current Page 1 of 17

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

2-(Cyclobutylamino)-N-[(2S)-3-(3,4-dihydro-2(1H)-isoquinolinyl)-2-hydroxypropyl]isonicotinamide

GSK591

EPZ015866

EPZ-015866

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What is the InChIKey of 2-(Cyclobutylamino)-N-[(2S)-3-(3,4-dihydro-2(1H)-isoquinolinyl)-2-hydroxypropyl]isonicotinamide?

A: InChIKey of 2-(Cyclobutylamino)-N-[(2S)-3-(3,4-dihydro-2(1H)-isoquinolinyl)-2-hydroxypropyl]isonicotinamide is TWKYXZSXXXKKJU-FQEVSTJZSA-N.

Q: What are the uses of 2-(Cyclobutylamino)-N-[(2S)-3-(3,4-dihydro-2(1H)-isoquinolinyl)-2-hydroxypropyl]isonicotinamide?

A: Main uses of 2-(Cyclobutylamino)-N-[(2S)-3-(3,4-dihydro-2(1H)-isoquinolinyl)-2-hydroxypropyl]isonicotinamide: EPZ015866 is a potent and selective inhibitor of protein methyltransferase 5 (PRMT5) with an IC50 of 22 nM.

Q: What is the molecular weight of 2-(Cyclobutylamino)-N-[(2S)-3-(3,4-dihydro-2(1H)-isoquinolinyl)-2-hydroxypropyl]isonicotinamide?

A: Molecular weight of 2-(Cyclobutylamino)-N-[(2S)-3-(3,4-dihydro-2(1H)-isoquinolinyl)-2-hydroxypropyl]isonicotinamide is 380.483.

Q: What is the SMILES notation of 2-(Cyclobutylamino)-N-[(2S)-3-(3,4-dihydro-2(1H)-isoquinolinyl)-2-hydroxypropyl]isonicotinamide?

A: SMILES notation of 2-(Cyclobutylamino)-N-[(2S)-3-(3,4-dihydro-2(1H)-isoquinolinyl)-2-hydroxypropyl]isonicotinamide is O=C(NCC(O)CN1CCc2ccccc2C1)c1ccnc(NC2CCC2)c1.

Q: What is the boiling point of 2-(Cyclobutylamino)-N-[(2S)-3-(3,4-dihydro-2(1H)-isoquinolinyl)-2-hydroxypropyl]isonicotinamide?

A: Boiling point of 2-(Cyclobutylamino)-N-[(2S)-3-(3,4-dihydro-2(1H)-isoquinolinyl)-2-hydroxypropyl]isonicotinamide is 648.4±55.0 °C at 760 mmHg.

Q: What is the English name of 2-(Cyclobutylamino)-N-[(2S)-3-(3,4-dihydro-2(1H)-isoquinolinyl)-2-hydroxypropyl]isonicotinamide?

A: The English name of 2-(Cyclobutylamino)-N-[(2S)-3-(3,4-dihydro-2(1H)-isoquinolinyl)-2-hydroxypropyl]isonicotinamide is 2-(Cyclobutylamino)-N-[(2S)-3-(3,4-dihydro-2(1H)-isoquinolinyl)-2-hydroxypropyl]isonicotinamide.

Q: What is the molecular formula of 2-(Cyclobutylamino)-N-[(2S)-3-(3,4-dihydro-2(1H)-isoquinolinyl)-2-hydroxypropyl]isonicotinamide?

A: Molecular formula of 2-(Cyclobutylamino)-N-[(2S)-3-(3,4-dihydro-2(1H)-isoquinolinyl)-2-hydroxypropyl]isonicotinamide is C22H28N4O2.

Q: What is the LogP of 2-(Cyclobutylamino)-N-[(2S)-3-(3,4-dihydro-2(1H)-isoquinolinyl)-2-hydroxypropyl]isonicotinamide?

A: LogP of 2-(Cyclobutylamino)-N-[(2S)-3-(3,4-dihydro-2(1H)-isoquinolinyl)-2-hydroxypropyl]isonicotinamide is 3.66.

Q: What is the CAS number of 2-(Cyclobutylamino)-N-[(2S)-3-(3,4-dihydro-2(1H)-isoquinolinyl)-2-hydroxypropyl]isonicotinamide?

A: CAS number of 2-(Cyclobutylamino)-N-[(2S)-3-(3,4-dihydro-2(1H)-isoquinolinyl)-2-hydroxypropyl]isonicotinamide is 1616391-87-7.

Q: What are the storage conditions for 2-(Cyclobutylamino)-N-[(2S)-3-(3,4-dihydro-2(1H)-isoquinolinyl)-2-hydroxypropyl]isonicotinamide?

A: Storage conditions for 2-(Cyclobutylamino)-N-[(2S)-3-(3,4-dihydro-2(1H)-isoquinolinyl)-2-hydroxypropyl]isonicotinamide: -20℃.

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Shanghai Nianxing Industrial Co., Ltd

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: EPZ015866
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

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Price: $145/10mM*1mLinDMSO

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EPZ015866(GSK591)

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The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.