1616391-87-7

1616391-87-7 structure

Name: EPZ015866(GSK591)
Chemical Name: 2-(Cyclobutylamino)-N-[(2S)-3-(3,4-dihydro-2(1H)-isoquinolinyl)-2-hydroxypropyl]isonicotinamide
CAS Number: 1616391-87-7
Molecular Formula: C₂₂H₂₈N₄O₂
Molecular Weight: 380.483
Catalog: Signaling Pathways Epigenetics Histone Methyltransferase
Create Date: 2018-01-05 01:58:27
Modify Date: 2025-08-26 11:10:37
EPZ015866 is a potent and selective inhibitor of protein methyltransferase 5 (PRMT5) with an IC50 of 22 nM.

Name	2-(Cyclobutylamino)-N-[(2S)-3-(3,4-dihydro-2(1H)-isoquinolinyl)-2-hydroxypropyl]isonicotinamide
Synonyms	4-Pyridinecarboxamide, 2-(cyclobutylamino)-N-[(2S)-3-(3,4-dihydro-2(1H)-isoquinolinyl)-2-hydroxypropyl]- 2-(Cyclobutylamino)-N-[(2S)-3-(3,4-dihydro-2(1H)-isoquinolinyl)-2-hydroxypropyl]isonicotinamide GSK591 EPZ015866 EPZ-015866

Description	EPZ015866 is a potent and selective inhibitor of protein methyltransferase 5 (PRMT5) with an IC50 of 22 nM.
Related Catalog	Signaling Pathways >> Epigenetics >> Histone Methyltransferase Research Areas >> Cancer
Target	IC50: 22 nM (PRMT5)[1]
References	[1]. [1] Kenneth W. Duncan et al. Structure and Property Guided Design in the Identification of PRMT5 Tool Compound EPZ015666. ACS Med. Chem. Lett., 2016, 7 (2), pp 162-166. [2]. [2] Elayne Chan-Penebre et al. A selective inhibitor of PRMT5 with in vivo and in vitro potency in MCL models. Nature Chemical Biology 11, 2015, 432-437