New N-(pyridin-4-yl)-(indol-3-yl) acetamides and propanamides as antiallergic agents

…, P Emig, U Achterrath, I Szelenyi, B Nickel…

Index: Menciu, Cecilia; Duflos, Muriel; Fouchard, Fabienne; Le Baut, Guillaume; Emig, Peter; Achterrath, Ute; Szelenyi, Istvan; Nickel, Bernd; Schmidt, Juergen; Kutscher, Bernhard; Guenther, Eckhardt Journal of Medicinal Chemistry, 1999 , vol. 42, # 4 p. 638 - 648

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Citation Number: 26

Abstract

A series of new N-(pyridin-4-yl)-(indol-3-yl) alkylamides 44-84 has been prepared in the search of novel antiallergic compounds. Synthesis of the desired ethyl (2-methyindol-3-yl) acetates 1-4 was achieved by indolization under Fischer conditions; Japp-Klingemann method followed by 2-decarboxylation afforded the ethyl (indol-3-yl) alkanoates 17-25. Amidification was successfully carried out by condensation of the corresponding acids or ...

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