Michael reaction of stabilized carbon nucleophiles catalyzed by [RuH2 (PPh3) 4]

E Gómez-Bengoa, JM Cuerva, C Mateo…

Index: Gomez-Bengoa, Enrique; Cuerva, Juan M.; Mateo, Cristina; Echavarren, Antonio M. Journal of the American Chemical Society, 1996 , vol. 118, # 36 p. 8553 - 8565

Full Text: HTML

Citation Number: 88

Abstract

The Michael reaction of active methylene compounds lacking cyano groups such as malonates, β-ketoesters, 1, 3-diketones, 1, 1-disulfones, nitrocompounds, Meldrum acid, and anthrone with common acceptors proceeds in acetonitrile solution in the presence of [RuH2 (PPh3) 4] as the catalyst. Cyano acetates, more acidic than malonates in organic solvents, are also excellent substrates for this reaction. In a number of cases, intramolecular aldol ...