Metal-and Oxidant-Free Synthesis of Quinazolinones from β-Ketoesters with o-Aminobenzamides via Phosphorous Acid-Catalyzed Cyclocondensation and Selective …

…, J Dong, X Chen, Q Li, Y Zhou, SF Yin

Index: Chen, Xiuling; Chen, Tieqiao; Zhou, Yongbo; Han, Daoqing; Han, Li-Biao; Yin, Shuang-Feng Organic and Biomolecular Chemistry, 2014 , vol. 12, # 23 p. 3802 - 3807

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Citation Number: 15

Abstract

A general and efficient phosphorous acid-catalyzed cyclocondensation of β-ketoesters with o-aminobenzamides via selective C–C bond cleavage leading to quinazolinones is developed. This reaction proceeds smoothly under metal-and oxidant-free conditions, giving