Asymmetric organocatalysis of the addition of acetone to 2-nitrostyrene using N-diphenylphosphinyl-1, 2-diphenylethane-1, 2-diamine (PODPEN)

…, AS Partridge, CV Manville, DT Racys, G Woodward…

Index: Morris, David J.; Partridge, A. Simon; Manville, Charles V.; Racys, Daugidas T.; Woodward, Gary; Docherty, Gordon; Wills, Martin Tetrahedron Letters, 2010 , vol. 51, # 1 p. 209 - 212

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Citation Number: 29

Abstract

The use of enantiomerically pure amines in organocatalysis has enjoyed a period of rapid recent development. 1, 2 and 3 Several of these reactions involve the formation of an active species (iminium or enamide) by a reversible condensation reaction between the amine catalyst and the carbonyl group in one of the reagents. In a large proportion of examples of amine-catalysed reactions, a second functional group in the catalyst serves to activate and direct the ...