Synthesis

Expedient Synthesis of Perhaloaldehyde N-Acyl Hemiaminals

L Ingrassia, M Mulliez

Index: Ingrassia, Laurent; Mulliez, Michel Synthesis, 1999 , # 10 p. 1731 - 1738

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Citation Number: 16

Abstract

Abstract: Various perhaloaldehyde N-acyl hemiaminals 1 are readily prepared in high yields by condensation of amides 7 with easily available perhaloaldehyde O-ethyl hemiacetals 8 or hydrates 9 in the presence of 5 Å molecular sieves. Key words: addition reactions, hemiaminals, fluorine, aldehydes, halides, pseudopeptidic transition state analogs, molecular sieves, perhalogenated aldehyde adducts, side chain peptides