Nucleic acid related compounds. 38. Smooth and high-yield iodination and chlorination at C-5 of uracil bases and p-toluyl-protected nucleosides

MJ Robins, PJ Barr, J Giziewicz

Index: Nowak, Ireneusz; Robins, Morris J. Organic Letters, 2005 , vol. 7, # 22 p. 4903 - 4905

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Citation Number: 91

Abstract

Treatment of uracil bases and protected nucleosides with iodine monochloride (ICl) gave the corresponding 5-iodouracil products in over 95% purified yields. Analogously facile chlorination was effected with iodobenzene dichloride (PhICl2). Protection of the

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