2-amino-phenoxazine-3-one attenuates glucose-induced augmentation of embryonic form of myosin heavy chain, endothelin-1 and plasminogen activator inhibitor-1 …

…, XF Che, S Akiyama, A Tomoda, S Chakrabarti…

Index: Fukuda, Gen; Yoshitake, Noriko; Khan, Zia Ali; Kanazawa, Masao; Notoya, Yoko; Che, Xiao-Fang; Akiyama, Shin-Ichi; Tomoda, Akio; Chakrabarti, Subrata; Odawara, Masato Biological and Pharmaceutical Bulletin, 2005 , vol. 28, # 5 p. 797 - 801

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Citation Number: 9

Abstract

The aim of this study was to investigate the changes in mRNA level of embryonic form of myosin heavy chain (SMemb), endothelin-1 (ET-1) and plasminogen activator inhibitor-1 (PAI-1), which are considered to be involved in the angiogenesis and atherosclerosis in diabetic blood vessels, in human umbilical vein endothelial cells (HUVECs) caused by high ambient glucose, and the effects of 2-aminophenoxazine-3-one (Phx-3), which was ...