Mimics of tryptophan synthetase and of biochemical dehydroalanine formation

W Weiner, J Winkler, SC Zimmerman…

Index: Weiner, Wayne; Winkler, Jeffrey; Zimmerman, Steven C.; Czarnik, Anthony W.; Breslow, Ronald Journal of the American Chemical Society, 1985 , vol. 107, # 13 p. 4093 - 4094

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Citation Number: 34

Abstract

We have described compounds consisting of pyridoxamine coupled to the primary side of@- cyclodextrin, 2 the secondary side of P-cy~ lodextrin,~ or a synthetic macrocyclic binding group. 4 These converted keto acids into amino acids with selectivity for substrates, such as indolepyruvic acid, that bound into the macrocyclic cavities while adopting the correct geometry for transamination. The enzyme tryptophan synthetase uses pyridoxal to ...