Tetrahedron

Brønsted acid-assisted N-alkylation of sulfonamides using ethers as the alkylation reagents

W Shi, CM Bai, K Zhu, DM Cui, C Zhang

Index: Shi, Wei; Bai, Chun-Mei; Zhu, Kai; Cui, Dong-Mei; Zhang, Chen Tetrahedron, 2014 , vol. 70, # 2 p. 434 - 438

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Citation Number: 4

Abstract

Abstract N-Alkylation of sulfonamides using cyclic ethers as alkylation reagents and Brønsted acid as a catalyst produced pyrrolidine and piperidine derivatives in good yields. When using symmetrical and unsymmetrical ethers as alkylation reagents, mono-N- alkylation of sulfonamides took place to afford the corresponding products.