A bulge binding agent with novel wedge-shape topology for stimulation of DNA triplet repeat strand slippage synthesis

L Liu, H Li, L Yi, X Yang, X Wen, Z Xi

Index: Liu, Liangliang; Li, Heyang; Yi, Long; Yang, Xing; Wen, Xin; Xi, Zhen Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 23 p. 6184 - 6188

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Citation Number: 9

Abstract

Expansion of DNA repeat sequences is associated with many human genetic diseases. Bulged DNA structures have been implicated as intermediates in DNA slippage within the DNA repeat regions. Herein a bulge binding agent with novel wedge-shape topology of the aromatic moiety was designed and synthesized. The compound–bulge DNA interactions were characterized via UV melting experiments, circular dichroism and were quantitated ...