Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 1986-05-01

Aneuploidy-inducing chemicals in yeast evaluated by the micronucleus test.

A Basler

Index: Mutat. Res. 174(1) , 11-3, (1986)

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Abstract

Chinese hamsters were exposed to acetone, methyl ethyl ketone, ethyl acetate and 2-methoxy ethyl acetate, known to be strong inducers of aneuploidy in the yeast Saccharomyces cerevisiae. All solvents yielded negative results in the micronucleus test, whereas the vinca alkaloid vindesine--used as a positive control substance--proved to act as a spindle poison in mammals in vivo.