Characterizing permeability and stability of microcapsules for controlled drug delivery by dynamic NMR microscopy.

Stefan Henning, Daniel Edelhoff, Benedikt Ernst, Sabine Leick, Heinz Rehage, Dieter Suter

Index: J. Magn. Reson. 221 , 11-8, (2012)

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Abstract

Microscopic capsules made from polysaccharides are used as carriers for drugs and food additives. Here, we use NMR microscopy to assess the permeability of capsule membranes and their stability under different environmental conditions. The results allow us to determine the suitability of different capsules for controlled drug delivery. As a measure of the membrane permeability, we monitor the diffusion of paramagnetic molecules into the microcapsules by dynamic NMR microimaging. We obtained the diffusion coefficients of the probe molecules in the membranes and in the capsule core by comparing the measured time dependent concentration maps with numerical solutions of the diffusion equation. The results reveal that external coatings strongly decrease the permeability of the capsules. In addition, we also visualized that the capsules are stable under gastric conditions but dissolve under simulated colonic conditions, as required for targeted drug delivery. Depending on the capsule, the timescales for these processes range from 1 to 28 h.Copyright © 2012 Elsevier Inc. All rights reserved.