Hypervalent Iodine (III) Sulfonate Mediated Synthesis of 6??Arylimidazo [2, 1??b] thiazoles in Liquid PEG??400

FW Wu, RS Hou, HM Wang, IJ Kang…

Index: Wu, Fang-Wen; Hou, Rei-Sheu; Wang, Huey-Min; Kang, Iou-Jiun; Chen, Ling-Ching Journal of the Chinese Chemical Society, 2011 , vol. 58, # 5 p. 663 - 666

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Abstract

Abstract PEG-400 [poly (ethylene glycol-400)] is used as reaction medium in the one-pot synthesis of 6-arylimidazo [2, 1-b] thiazoles by reaction with aryl ketones, hypervalent iodine (III) sulfonate and 2-aminothiazole. Significant rate enhancements and improved yields have been observed.