Clinical toxicology 1980-03-01

Chelation in metal intoxication. VIII. Removal of chromium from organs of potassium chromate administered rats.

J R Behari, S K Tandon

Index: Clin. Toxicol. 16(1) , 33-40, (1980)

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Abstract

Some polyaminocarboxylic acids were examined for their ability to mobilize chromium from certain vital organs, their subcellular fractions, and blood cells of potassium chromate administered rats. Hexamethylene 1,6-diamino tetraacetic acid (TDTA), triethylene tetramine hexaacetic acid (TTHA), and ethylene diamine di (O-hydroxylphenyl acetic acid) (EDDHA) may be useful in preventing or reducing chromate toxicity. No definite relationship could be observed between the structure of the chelating agents and their chromium-removing capacity.