Biochemical Pharmacology 1986-10-15

Compounds that inhibit chymotrypsin and cell replication.

B Goz, C Ganguli, M Troconis, S Wyrick, K S Ishaq, J A Katzenellenbogen

Index: Biochem. Pharmacol. 35(20) , 3587-91, (1986)

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Abstract

Several compounds have been tested for their ability to inhibit bovine pancreatic alpha-chymotrypsin (Ki) and their ability to inhibit cell replication (IC50). There is good agreement over three orders of magnitude between the Ki and the IC50 values of these compounds. The data support the hypothesis that a cellular, chymotrypsin-like activity is necessary for cell replication.