Design, synthesis, and molecular modeling studies of 5′-deoxy-5′-ureidoadenosine: 5′-ureido group as multiple hydrogen bonding donor in the active site of S- …

…, HJ Lee, DK Tosh, HO Kim, S Pal, S Choi, Y Lee…

Index: Wang, Ting; Lee, Hyun Joo; Tosh, Dilip K.; Kim, Hea Ok; Pal, Shantanu; Choi, Sun; Lee, Yoonji; Moon, Hyung Ryong; Zhao, Long Xuan; Lee, Kang Man; Jeong, Lak Shin Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 16 p. 4456 - 4459

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Citation Number: 8

Abstract

5′-Deoxy-5′-ureidoadenosine was designed and synthesized as a potent inhibitor of S- adenosylhomocysteine hydrolase (SAH), in which 5′-ureido group acted as multiple hydrogen bonding donor in binding with active site residues of SAH in the molecular modeling study.