Preliminary SAR analysis of novel antiproliferative N 6, 5′-bis-ureidoadenosine derivatives

MA Peterson, M Oliveira, MA Christiansen…

Index: Peterson, Matt A.; Oliveira, Marcelio; Christiansen, Michael A.; Cutler, Christopher E. Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 23 p. 6775 - 6779

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Citation Number: 15

Abstract

A preliminary library of novel N6, 5′-bis-ureidoadenosine analogs and related derivatives was prepared and tested for activity against the NCI 60 panel of human cancers. A 2′-O- TBS group was found to be necessary, but not sufficient, for optimal antiproliferative activity. Neither the N6-nor 5′-ureido substituents were sufficient to achieve significant antiproliferative effects when present in the absence of the other. The 2′-O-TBS, and N6, ...