International Journal of Antimicrobial Agents 2001-12-01

In vitro activity of the chelating agents nitroxoline and oxine against Mycobacterium bovis BCG.

B Murugasu-Oei, T Dick

Index: Int. J. Antimicrob. Agents 18(6) , 579-82, (2001)

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Abstract

The chelating antibiotic nitroxoline (5-nitro-8-hydroxyquinoline) showed a bacteriostatic effect at a concentration of 10 microM for Mycobacterium bovis BCG. At higher concentrations the compound showed moderate cidal activity against growing bacilli. In contrast, its non-nitrated derivative oxine (8-hydroxyquinoline, MIC=2 microM) reduced the viability of a growing culture rapidly, 5000-fold at a concentration where the nitroxoline was merely bacteriostatic. Both compounds showed appreciable cidal activity against bacilli in their hypoxic dormant state.