e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521

Dérivés de la dihydro??2, 4 triazole??1, 2, 4 thione??3 et de l'amino??2 thiadiazole??1, 3, 4 à partir de nouvelles thiosemicarbazones d'esters

F Malbec, R Milcent, G Barbier

Index: Malbec, Frederique; Milcent, Rene; Barbier, Geo Journal of Heterocyclic Chemistry, 1984 , vol. 21, p. 1689 - 1698

Full Text: HTML

Citation Number: 41

Abstract

Abstract Une nouvelle synthèse générale des dihydro-2, 4 triazole-1, 2, 4 thiones-3 disubstituées en position 4 et 5 est proposée. Ces hétérocycles sont obtenus par action d'amines primaires, d'arylhydrazines ou d'aroylhydrazines sur les thiosemicarbazones d'esters. Celles-ci sont préparées par action de chlorhydrates d'iminoéthers sur la thiosemicarbazide dans le diméthylformamide. Les thiosemicarbazones se prêtent à d' ...

N/A Structure

Benzohydrazide Structure

~91%

Benzamide,N-(1,5-dihydro-3-phenyl-5-thioxo-4H-1,2,4-triazol-4-yl)- Structure

Benzamide,N-(1,...

Ethyl benzimidate hydrochloride Structure

Ethyl benzimida...

~%

Benzamide,N-(1,5-dihydro-3-phenyl-5-thioxo-4H-1,2,4-triazol-4-yl)- Structure

Benzamide,N-(1,...

Benzamide,N-(1,5-dihydro-3-phenyl-5-thioxo-4H-1,2,4-triazol-4-yl)- Structure

Benzamide,N-(1,...

~80%

3,6-diphenyl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole Structure

3,6-diphenyl-[1...

Ethyl benzimidate hydrochloride Structure

Ethyl benzimida...

~%

3,6-diphenyl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole Structure

3,6-diphenyl-[1...

N/A Structure

~%

3,6-diphenyl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole Structure

3,6-diphenyl-[1...

Benzohydrazide Structure

~%

3,6-diphenyl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole Structure

3,6-diphenyl-[1...

2-Aminopyridine Structure

2-Aminopyridine

N/A Structure

~23%

3-phenyl-4-pyridin-2-yl-1H-1,2,4-triazole-5-thione Structure

3-phenyl-4-pyri...

Ethyl benzimidate hydrochloride Structure

Ethyl benzimida...

~%

3-phenyl-4-pyridin-2-yl-1H-1,2,4-triazole-5-thione Structure

3-phenyl-4-pyri...

ethyl (Z)-N-carbamothioylbutyrohydrazonate Structure

ethyl (Z)-N-car...

~41%

5-propyl-[1,3,4]thiadiazol-2-ylamine Structure

5-propyl-[1,3,4...

3H-1,2,4-Triazole-3-thione,1,2-dihydro-5-propyl-(9CI) Structure

3H-1,2,4-Triazo...

N/A Structure

~67%

3-(4-METHYLPHENYL)-1H-1,2,4-TRIAZOLE-5-THIOL Structure

3-(4-METHYLPHEN...

5-(p-Tolyl)-1,3,4-thiadiazol-2-amine Structure

5-(p-Tolyl)-1,3...

ethyl 4-methylbenzimidate hydrochloride Structure

ethyl 4-methylb...

~%

5-(p-Tolyl)-1,3,4-thiadiazol-2-amine Structure

5-(p-Tolyl)-1,3...

ethyl N-carbamothioyl-2-phenylethanehydrazonate Structure

ethyl N-carbamo...

Benzylamine Structure

~73%

4,5-Dibenzyl-3-sulphanyl-4H-1,2,4-triazole, 4,5-Dibenzyl-4H-1,2,4-triazole-3-thiol Structure

4,5-Dibenzyl-3-...

Benzeneethanimidicacid, ethyl ester, hydrochloride (1:1) Structure

Benzeneethanimi...

~%

4,5-Dibenzyl-3-sulphanyl-4H-1,2,4-triazole, 4,5-Dibenzyl-4H-1,2,4-triazole-3-thiol Structure

4,5-Dibenzyl-3-...

N/A Structure

~%

5-Phenyl-1,3,4-thiadiazol-2-amine Structure

5-Phenyl-1,3,4-...

Ethyl benzoate Structure

N/A Structure

Structure

~44%

5-ethyl-4-phenyl-4H-1,2,4-triazole-3-thiol Structure

5-ethyl-4-pheny...

Benzeneethanimidicacid, ethyl ester, hydrochloride (1:1) Structure

Benzeneethanimi...

Thiosemicarbazide Structure

Thiosemicarbazide

~53%

ethyl N-carbamothioyl-2-phenylethanehydrazonate Structure

ethyl N-carbamo...

ethyl N-carbamothioyl-4-chlorobenzohydrazonate Structure

ethyl N-carbamo...

~19%

5-(4-Chlorophenyl)-4H-1,2,4-triazole-3-thiol Structure

5-(4-Chlorophen...

5-(4-chlorophenyl)-1,3,4-thiadiazol-2-amine Structure

5-(4-chlorophen...

4-Chlorobenzimidoyl Ethyl Ether Hydrochloride Structure

4-Chlorobenzimi...

~%

5-(4-Chlorophenyl)-4H-1,2,4-triazole-3-thiol Structure

5-(4-Chlorophen...

N/A Structure

Structure

~56%

4,5-Diphenyl-4H-1,2,4-triazole-3-thiol Structure

4,5-Diphenyl-4H...

ethyl N-carbamothioyl-4-chlorobenzohydrazonate Structure

ethyl N-carbamo...

Structure

~47%

5-(4-CHLORO-PHENYL)-4-PHENYL-4H-[1,2,4]TRIAZOLE-3-THIOL Structure

5-(4-CHLORO-PHE...