Angewandte Chemie. International edition in English 2012-07-09

Continuous synthesis and purification by direct coupling of a flow reactor with simulated moving-bed chromatography.

Alexander G O'Brien, Zoltán Horváth, François Lévesque, Ju Weon Lee, Andreas Seidel-Morgenstern, Peter H Seeberger

Index: Angew. Chem. Int. Ed. Engl. 51(28) , 7028-30, (2012)

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Abstract

Continuous synthesis meets continuous purification to produce pure products from crude reaction mixtures. In the nucleophilic aromatic substitution of 2,4-difluoronitrobenzene with morpholine the desired monosubstituted product can be continuously separated from the byproducts in a purity of over 99 % by coupling a flow reactor to a simulated moving bed (SMB) chromatography module.Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.