The Journal of organic chemistry

A Catalyst-Free Benzylic C–H Bond Olefination of Azaarenes for Direct Mannich-like Reactions

Y Yan, K Xu, Y Fang, Z Wang

Index: Yan, Yizhe; Xu, Kun; Fang, Yang; Wang, Zhiyong Journal of Organic Chemistry, 2011 , vol. 76, # 16 p. 6849 - 6855

Full Text: HTML

Citation Number: 72

Abstract

A highly efficient synthesis of trans-alkenylazaarene under catalyst-free conditions was developed via the addition of methylazaarenes to N-sulfonyl aldimines and a subsequent C– N elimination in situ. A one-pot procedure for this addition–elimination was also developed. The reaction could tolerate a broad substrate scope and give the corresponding alkenylazaarenes in high yields.

 Related Synthetic Route

~94%

Learn More

~84%

Learn More

~%

Learn More

~95%

Learn More

~87%

Learn More

~89%

Learn More

~90%

Learn More

~94%

Learn More

~97%

Learn More

~87%

Learn More

~83%

Learn More

~86%

Learn More

~66%

Learn More

~%

Learn More

~%

Learn More

~%

Learn More

~%

Learn More

~%

Learn More

~95%

Learn More

~89%

Learn More

~98%

Learn More

~97%

Learn More