Bioorganic & Medicinal Chemistry Letters 2007-07-15

Discovery of para-alkylthiophenoxyacetic acids as a novel series of potent and selective PPARdelta agonists.

Rui Zhang, Aihua Wang, Alan DeAngelis, Patricia Pelton, Jun Xu, Peifang Zhu, Lubing Zhou, Keith Demarest, William V Murray, Gee-Hong Kuo

Index: Bioorg. Med. Chem. Lett. 17(14) , 3855-9, (2007)

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Abstract

A novel series of potent and selective PPARdelta agonists, para-alkylthiophenoxyacetic acids, was identified. The synthesis and structure-activity relationships are described.