Bioorganic & Medicinal Chemistry Letters 2009-02-15

Discovery and SAR of para-alkylthiophenoxyacetic acids as potent and selective PPARdelta agonists.

Rui Zhang, Alan Deangelis, Aihua Wang, Ellen Sieber-McMaster, Xun Li, Ronald Russell, Patricia Pelton, Jun Xu, Peifang Zhu, Lubing Zhou, Keith Demarest, William V Murray, Gee-Hong Kuo

Index: Bioorg. Med. Chem. Lett. 19(4) , 1101-4, (2009)

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Abstract

Synthesis and SAR of para-alkylthiophenoxyacetic acids is described. Achiral compounds 30, 31 and 32 were identified as potent and selective PPARdelta agonists.