e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521
Synthesis
Stereoselective Synthesis of Aporphine Alkaloids Using a Hypervalent Iodine (III) Reagent-Promoted Oxidative Nonphenolic Biaryl Coupling Reaction. Total Synthesis …
Abstract The aporphine alkaloid (+)-glaucine (8a) and two other analogues 8b, c have been synthesized in good yield and high ee from the appropriate 1, 2-diarylethylamine derivatives, which were in turn prepared using (S)-(+)-phenylglycinol as chiral support. Next, a sequence of simple transformations: N-alkylation with bromoacetaldehyde diethyl acetal, N-methylation, Pommeranz-Fritsch cyclization, and ionic hydrogenation led to the key ...
