Synthesis and anticancer structure activity relationship investigation of cationic anthraquinone analogs

JP Shrestha, MY Fosso, J Bearss…

Index: Shrestha, Jaya P.; Fosso, Marina Y.; Bearss, Jeremiah; Chang, Cheng-Wei Tom European Journal of Medicinal Chemistry, 2014 , vol. 77, p. 96 - 102

Full Text: HTML

Citation Number: 14

Abstract

Abstract We have synthesized a series of novel 4, 9-dioxo-4, 9-dihydro-1H-naphtho [2, 3- d][1, 2, 3] triazol-3-ium salts, which can be viewed as analogs of cationic anthraquinones. Unlike the similar analogs that we have reported previously, these compounds show relatively weak antibacterial activities but exert strong anticancer activities (low μM to nM GI 50), in particular, against melanoma, colon cancer, non-small cell lung cancer and central ...