Synthesis

Convenient synthesis of carboxylic acid anhydrides using N, N-bis [2-oxo-3-oxazolidinyl] phosphorodiamidic chloride

J Cabre-Castellvi, A Palomo-Coll, AL Palomo-Coll

Index: Cabre-Castellvi, J.; Palomo-Coll, A.; Palomo-Coll, A.L. Synthesis, 1981 , # 8 p. 616 - 620

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Citation Number: 20

Abstract

Many methods for the conversion of carboxylic acids into the corresponding acid anhydrides using two-stage, one-flask pro-cedures or one-stage procedures with various reagents have been described"“-" M5 and reviewed “. The yields and the reaction conditions employed vary widely; reaction times from 30 min to 20 h, reaction temperatures from room temper-ature to reﬂux in acetic anhydride.

~97%

~73%

~96%

~97%

~99%

~95%

~96%

~90%

~10%

~99%

~93%

~10%

~98%

~93%

~99%

~97%

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