Journal of neural transmission. Supplementum 1994-01-01

Kinetics of inhibition of MAO-B by N-(2-aminoethyl)-p-chlorobenzamide (Ro 16-6491) and analogues.

E L Mullan, C H Williams

Index: J. Neural Transm. Suppl. 41 , 307-11, (1994)

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Abstract

Ro 16-6491 is known to be a potent reversible inhibitor of human brain MAO-B. This compound and several analogues were tested for their effect on bovine liver MAO-B. It was found that in compounds where the amide bond of Ro 16-6491 was replaced by an ester bond an increase in potency of the order of 150-200 times was obtained.