Toxicology Letters 1981-03-01

Elimination pattern and biodistribution of [14C]chlorferron in rats.

J K Malik, J P Lay, W Klein, F Korte

Index: Toxicol. Lett. 7(6) , 449-52, (1981)

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Abstract

Administration of [14C]chlorferron in a single oral dose of 0.5 and 20 mg/kg body weight to female rats resulted in a urinary excretion of greater than 74% of the given dose during the first 24 h. Approx. 8% of the dose was eliminated in faeces within 7 days. 7 days after dosing, very low levels of [14C]chlorferron-derived residues were detected in all analyzed organs. These findings indicated that chlorferron was absorbed from the gastro-intestinal tract in appreciable quantities, but was rapidly excreted mainly via the urine with small amounts only in the faeces.