Organic letters

Nitroepoxides as Versatile Precursors to 1, 4-Diamino Heterocycles

A Vidal-Albalat, S Rodriguez, FV Gonzalez

Index: Vidal-Albalat, Andreu; Rodriguez, Santiago; Gonzalez, Florenci V. Organic Letters, 2014 , vol. 16, # 6 p. 1752 - 1755

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Citation Number: 12

Abstract

Nitroepoxides are easily transformed into 1, 4-diamino heterocycles such as quinoxalines and pyrazines by treatment with 1, 2-benzenediamines and ammonia, respectively. Additionally, related saturated heterocycles, such as piperazines and tetrahydroquinoxalines, can be accessed by treatment with 1, 2-diamines and a reducing agent. These transformations are efficient, provide access privileged, bioactive structures, ...

~86%

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