Neuroscience Letters 1990-05-04

Duodenal SP-like immunoreactivity is decreased in experimentally-induced duodenal ulcers.

S Evangelista, D Renzi, P Mantellini, C Surrenti, A Meli

Index: Neurosci. Lett. 112(2-3) , 352-5, (1990)

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Abstract

Substance P-like immunoreactivity (SP-li) is decreased in duodenal samples of animals treated with a single dose of an ulcerogen such as dulcerozine, mepirizole or cysteamine. Unlike dulcerozine- or mepirizole-induced ulcers the degree of cysteamine-induced duodenal lesions is inversely correlated with the levels of duodenal SP-li. A significant decrease in duodenal SP-li was observed at 24 h, but not at 6 h after a single oral dose of cysteamine. These findings show that endogenous SP may play an important local role in duodenal ulcerogenesis.